Description
Pregnenolone is a prohormone synthesized in the brain and adrenals, but also in the liver, skin, brain, testicles, ovaries, and retina. As a biochemical precursor to DHEA and progesterone, pregnenolone helps maintain a normal balance between these hormones in the body. As a result, it helps modulate the cortisol-driven stress response system, supports nerve cell growth, and modulates mood.
Deficiency
Pregnenolone levels naturally peak during youth and begin a long, slow decline with age. Since pregnenolone is the parent compound of other vital neurosteroids such as DHEA declining levels of pregnenolone could leave brain cells increasingly vulnerable to overstimulation by neurotransmitters like glutamate, thereby affecting mood and cognition.
Mood Regulation
Research has shown pregnenolone to be beneficial for mood support and balance. Specifically, it is reported to have a positive effect on neuronal excitability and synaptic plasticity and has many other functions associated with mood regulation, neuroprotection from free radicals, balancing the stress response, and improving cognitive performance.
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