Noble ProBio Immune


Noble ProBio Immune is a spore-based, broad-spectrum probiotic formula designed to promote a healthy gut microflora, protect mucosal integrity, and relieve small intestinal bacterial overgrowth (SIBO). Each capsule provides key Bacillus spore- forming probiotic strains that remain in a dormant protective state in the harsh gastrointestinal environment yet become active on target to colonize and recondition the gut. Uniquely included in this formula are serum-derived bovine immunoglobulins that bind to microbes and toxins that are common in SIBO.


  • Helps Maintain Normal Gastrointestinal Balance
  • Provides Concentrated Immunoglobulins to Enhance Mucosal Immunity
  • Supports Digestion and Micronutrient Absorption
  • Maintains GI Barrier Health and Integrity



SIBO is a condition that occurs when there is an overabundance of commensal bacteria from the colon present in the small intestine. SIBO is largely overlooked and more prevalent than previously thought. The health of the small intestines relies on balanced microbiota, and probiotics and immunoglobulins can contribute to that balance by having a positive influence on the intestinal environment, including pH, organism diversity, and immune signaling.

Bacillus coagulans has been shown to increase the commensal GI microbiota. Supplementation of 1 billion CFU daily for 28 days with B. coagulans significantly increased levels of the commensal microbe F. prausnitzii from baseline compared to placebo, as well as increased Bacillus spp. in fecal samples of adults over 65. Bacillus coagulans has also been shown to relieve GI discomfort and improve stool consistency. Bacillus coagulans given once a day for eight weeks showed reduced daily bowel movements and GI symptoms. B. coagulans also significantly improved bowel movements in healthy adults with occasional constipation, as well as decreased abdominal discomfort.

Bacillus clausii is commonly used as a probiotic to promote balance in the microbiome and has showed promising results in individuals with SIBO specifically. B. clausii has demonstrated significant effectiveness in adults with acute diarrhea. B. clausii has also shown to significantly reduce duration of occasional diarrhea and decreased stool frequency in children.

Bacillus subtilis has been shown to relieve GI distress in patients. Bacillus subtilis supplementation of 1-3 billion CFU alongside motility stimulating agents was shown effective for relief of GI symptoms at four weeks.

Serum-Derived Bovine Immunoglobulins probiotics are a natural choice for supporting beneficial bacteria in the gut, but supplementation to eliminate unwanted microbes should also be considered.


Noble Naturals


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